BEACON TRANSCRIPT – Scientists working for the ReDo project discovered that a back pain relief can be used to treat cancer. The committee working for the Repurposing Drugs in Oncology program have reasons to think that non-steroidal anti-inflammatory medicine could be employed to keep cancerous cells in check.
What are NSAIDs?
The back pain relief brought forth is called Diclofenac. This drug belongs to a pharmacological group called NSAIDs or non-steroidal anti-inflammatory drugs. NSAID’s are typically used as painkillers, antipyretics and as anti-inflammatories when they are prescribed in high doses.
In this pharmaceutical class, the most known drugs are diclofenac, aspirin, naproxen, and ibuprofen. When used in treatments, NSAID’s have the capability of inhibiting the COX-1 and COX-2 enzymes, which, in terms, leads to the suppression of thromboxane and prostaglandins.
These type of drugs are not without a label of warning. Recent research has uncovered that NSAIDs, especially aspirin, are capable of producing ulcers and gastrointestinal bleeding.
NSAIDs and Cancer
New research data provided by the ReDo committee has confirmed that a back pain relief can be used to treat cancer. More specifically, diclofenac can be used as an adjuvant in chemotherapy and radiotherapy. Lab results performed on mice determined that subjects undergoing radiation or chemo, respond better to treatment if an NSAID is used.
Pan Pantziarka, Ph.D., who is also involved in the Repurposing Drugs in Oncology project, stated that we can’t even begin to comprehend all the effects of the drugs we use today. It may be that a simple remedy like Diclofenac could hold the key to treating a life-threatening disease such as cancer.
From a historical point of view, this is not the first time someone attempted to study the intimate relation between NSAIDs and cancer. Back in 1994, a team of researchers studied the effects of NSAIDs on a cancerous outgrowth in lab conditions. They later theorized that this group of drugs might impede certain types of cancer.
Subsequent mice experiments have revealed that their intuition was correct. Experimenting on mice with colorectal cancer, the team has discovered that if they used a Diclofenac solution, in combination with chemo, the tumors would stop growing.
This combo treatment proved to be effective in other types of cancer as well. Far from being the wonder cure, we are all expecting, this new study could pave the way to other oncology fields of interest.
The same doctor working for the ReDo project said that the tumor-halting mechanism is still somewhat of a mystery, but there are many scientists who think that diclofenac might be interacting with certain checkpoint inhibitors.
The conclusion of their study is that a back pain relief can be used to treat cancer, but it still is far from being an actual cure.