BEACON TRANSCRIPT – A research started by the Perelman School of Medicine of University of Pennsylvania claims to have found a way for wounds to heal without developing scar tissue.
The study expanded and included researchers from the University of California, of the Plikus Laboratory for Developmental and Regenerative Biology. The main researchers stated that they could manipulate the process of healing in order to end in skin regeneration and not scarring.
Dr. George Cotsarelis, the leader of the study, explained the regeneration process. The hair follicles must be allowed to regenerate first and the fat afterwards. Thus, the regenerating skin will share the aspect with the skin surrounding it.
The cells found in a healing wound are myofibroblasts, which were formerly thought to only develop scar tissue. However, the researchers found that these cells can also form fat cells similar to the healthy ones surrounding the wound if they are developed after the hair follicles.
While studying myofibroblasts, they found what was prompting these cells to become fat cells. The substance is called Bone Morphogenetic Protein (BMP). Formerly, it was believed that this type of cells could not evolve into other type of cells, hence the scar tissue. But researchers found that they can be influenced into becoming adipocytes, after a certain amount of time passed since the production of the wound.
Apart from the prevention of scar tissue after healing, the research can be used in order to prevent fat tissue loss. The loss of adipocytes is a common side effect which appears in the treatment of many viruses, including HIV. There is no method of treatment known to work for this condition, but this research might open the way for the prevention and regeneration of fat tissue.
A big amount of fat tissue is lost during the aging process. So many fat cells are lost that people remain with deep wrinkles that are impossible to be treated by the current anti-aging methods. The regeneration of the adipocytes can work well in this field, too.
The outcome of this research may be profitable for quite a number of people. Victims of accidents now have a chance of a complete regeneration of their wounds, people suffering from different conditions can prevent the sudden fat tissue loss, and aging people can treat their deep wrinkles. Not to mention that pharmaceutical companies can benefit a lot from the profit these treatments may bring.
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